Abstract
Methotrexate is a widely used medication with an array of recognized side effects. The present report describes a case of methotrexate-induced pneumonitis in a patient with psoriasis, and demonstrates the hallmark clinical and investigational findings that support this infrequently encountered diagnosis. The ensuing discussion reviews the pathogenesis, management and prevention of this adverse drug reaction.
Highlights
Methotrexate is a widely used medication with an array of recognized side effects
Prompt recognition of interstitial pneumonitis is essential before it progresses to irremediable pulmonary fibrosis
Clinical features Patients characteristically present with a history of progressive respiratory complaints within one year of initiating MTX therapy [3]
Summary
Methotrexate is a widely used medication with an array of recognized side effects. The present report describes a case of methotrexate-induced pneumonitis in a patient with psoriasis, and demonstrates the hallmark clinical and investigational findings that support this infrequently encountered diagnosis. Pretest ● What are the major clinical features supporting a diagnosis of MTX-induced pneumonitis? The patient’s clinical presentation, in addition to subsequent investigational findings, supported a diagnosis of interstitial pneumonitis resulting from an idiosyncratic reaction to MTX. Clinical features Patients characteristically present with a history of progressive respiratory complaints within one year of initiating MTX therapy [3].
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