Abstract
Allergy to antibiotics in children: Perception versus reality.
Highlights
An adverse reaction to an antibiotic is “any response to a drug which is noxious and unintended, and which occurs at doses used in man for prophylaxis, diagnosis, or treatment” [10]
When children with reported allergies to penicillin are subjected to skin testing, a range of 0% to 34% will have an immunoglobulin E (IgE)-type reaction [16,17,18,19,20]
The variation in the reported frequency of allergies among those who are labelled as antibiotic-allergic before skin testing is likely due, in some part, to differences in physician management of the initial clinical event that leads to suspicion of drug allergy
Summary
An adverse reaction to an antibiotic is “any response to a drug which is noxious and unintended, and which occurs at doses used in man for prophylaxis, diagnosis, or treatment” [10]. When children with reported allergies to penicillin are subjected to skin testing, a range of 0% to 34% will have an IgE-type reaction [16,17,18,19,20]. The variation in the reported frequency of allergies among those who are labelled as antibiotic-allergic before skin testing is likely due, in some part, to differences in physician management of the initial clinical event that leads to suspicion of drug allergy.
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