Abstract
Methotrexate is used for psoriasis by the majority of teaching services of dermatology in the United States. Three modes of administration were compared: small daily doses by mouth in interrupted schedules, single large weekly oral doses, and parenteral doses. All methods were effective and had toxicity, but the parenteral route showed the greatest toxicity. The drug is contraindicated in pregnancy, hematological disorders, peptic ulceration, and liver disease. Chromosomal breaks have been reported with greater frequency than normal. Renal clearance is vital. The drug should be considered only for very severe forms of psoriasis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
