IDDF2019-ABS-0240 Overlapping symptoms of peptic ulcer and gastroesophageal reflux disease of patients presenting with dyspepsia syndrome in karawaci, banten, indonesia

Abstract

Background The dyspepsia symptoms including epigastric pain, throbbing pain, fullness, bloating, tenderness, colicky pain, mouth bitterness, heartburn, abdominal pain, vomit and decreased appetite. The dyspepsia symptoms of peptic ulcer and gastroesophageal reflux disease often overlap. Dyspepsia symptoms and disease subtypes in Asian countries were different compared to Western countries. The aim of this study is to discover the association between dyspepsia symptoms in Karawaci, Banten, Indonesia as one of the Asian countries and the diagnosis of peptic ulcer and gastroesophageal reflux disease based on endoscopy. Methods This retrospective study used medical records of patients admitted with complaints of dyspepsia in Siloam General Hospital in Karawaci, Banten, Indonesia. Risk factors associated with peptic ulcer and gastroesophageal reflux disease such as epidemiological and clinical data collected were gender, age, symptoms, and results of endoscopy. Association between risk factors and peptic ulcer or gastroesophageal reflux disease were analyzed using Chi-Square Test and Fisher Test(bivariate analysis) and Logistic Regression (multivariate analysis). Results A total of 199 patients with dyspepsia symptoms were admitted on the period of 2017–2018, which 51 patients undergoing upper gastrointestinal endoscopy. The dyspepsia symptoms were the complaints the patients reported, including epigastric pain, throbbing pain, fullness, bloating, tenderness, mouth bitterness, heartburn, abdominal pain, vomit and decreased appetite. There were 33 patients with upper gastrointestinal endoscopy findings in accordance with peptic ulcer and gastroesophageal reflux disease. Bivariate analysis showed risk factors associated with peptic ulcer disease were epigastric pain (OR=1.778, 95% CI 0.889 - 3.555, p= 0.135), bloating (OR=0.419, 95% CI 0.277 - 0.635, p=0.199), and abdominal pain (OR=2.560, 95% CI 0.774- 8.809, p=0.064). Multivariate analysis showed a risk factor associated with peptic ulcer disease was abdominal pain (OR=5.333, 95% CI 0.885- 32.156, p=0.068). Conclusions Abdominal pain was the only risk factor associated with peptic ulcer disease and it was not statistically significant. There were overlapping dyspepsia symptoms among patients with peptic ulcer or gastroesophageal reflux disease in Karawaci, Banten, Indonesia.