Abstract
Background and objectives: The shared pathogenesis of psoriasis and atherosclerosis may be determined by assaying the levels of endothelial activation molecules. This study aimed at evaluating vascular cell adhesion molecule 1 (VCAM-1) and E-selectin serum concentrations, and atherosclerosis severity in patients with plaque psoriasis. It also aimed to determine the effects of methotrexate/adalimumab treatment for 12 weeks on the plasma levels of the aforementioned molecules. Materials and Methods: The study included 34 psoriasis patients (17 treated with methotrexate and 17 treated with adalimumab) and eight controls. The 10-year risk of a fatal cardiovascular disease, body mass index, Psoriasis Area and Severity Index, and body surface area were calculated for each subject. VCAM-1 and E-selectin levels were determined via an enzyme-linked immunosorbent assay at baseline and after 12 weeks. Results: Baseline E-selectin and VCAM-1 levels were higher in the adalimumab group than in the methotrexate and control groups. VCAM-1 levels decreased in the adalimumab (p = 0.02) and methotrexate groups (p = 0.008), while E-selectin levels decreased in the methotrexate group (p = 0.004). Conclusions: The results indicate a correlation between systemic psoriasis treatment and E-selectin and VCAM-1 plasma concentrations, which may be associated with the risk of cardiovascular disease development.
Highlights
Epidemiological data have provided evidence of an association between psoriasis and adverse cardiovascular outcomes [1]
body mass index (BMI) was significantly higher in the psoriasis group than in the control group (p = 0.001)
The results of our study highlight a relationship between the severity of psoriasis as described via Psoriasis Area and Severity Index (PASI) and body surface area (BSA) with BMI and the levels of vascular cell adhesion molecule 1 (VCAM-1) and E-selectin
Summary
Epidemiological data have provided evidence of an association between psoriasis and adverse cardiovascular outcomes [1] This association may be determined by assessing their shared pathogenesis involving endothelial dysfunction [2,3]. Vascular cell adhesion molecule 1 (VCAM-1) is an inducible glycoprotein, and E-selectin is a soluble cell adhesion molecule. This study aimed at evaluating vascular cell adhesion molecule 1 (VCAM-1) and E-selectin serum concentrations, and atherosclerosis severity in patients with plaque psoriasis. Results: Baseline E-selectin and VCAM-1 levels were higher in the adalimumab group than in the methotrexate and control groups. Conclusions: The results indicate a correlation between systemic psoriasis treatment and E-selectin and VCAM-1 plasma concentrations, which may be associated with the risk of cardiovascular disease development
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