Abstract
SUMMARY Three methods for elevation of end-expiratory Pco 2 at the end of prolonged hyper-ventilation have been studied in 44 anaesthetized patients. The most rapid and repeatable method was the addition of 5 per cent carbon dioxide to the inspired gas for 5 minutes. This raised the end-expiratory Pco 2 from a mean value of 21.4 mm Hg to 41.8 mm Hg, and was associated with an onset of spontaneous respiration in a mean time of 2.2 min. Hypoventilation with a minute volume of 3 l./min for 5 minutes with a rebreathing circuit, without soda-lime, gave a slow rise of Pco 2 (mean rate 3 mm Hg/min) with a resumption of spontaneous respiration in a mean time of 4.5 min. Step reduction of minute volume from 10 to 5 l./min without rebreathing was a very slow and variable method of raising end-expiratory Pco 2 , with a mean time of 5.2 min before the restoration of spontaneous breathing.
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