Abstract
A simple method is proposed to estimate the total body clearance and biological half-life of drugs in patients by determining two blood or plasma levels of drugs separated by an appropriate interval during the constant-rate intravenous infusion. The method is based on the assumptions that the drug disposition in the body can be adequately described by the linear onecompartment open model and its apparent volume of distribution can be estimated with a reasonable degree of accuracy from the literature data. The validity of this newly proposed method was demonstrated in three rabbits using theophylline as a test drug. Results of theoretical error analyses indicate that the method is potentially useful in providing an early guide for dosing adjustments for those potent drugs whose elimination rates have been shown to vary greatly in patients. The method may be particularly useful in patients with changing elimination kinetics of drugs. Effects of the accuracy in Vdestimate, plasma level assay, and sampling time interval on the error of total body clearance estimation are discussed.
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