Estimation of parameters of linear two-compartment open models with constant intravenous infusion using early blood level data

Abstract

In previous reports methods of estimating the parameters of the linear one-compartment open model with a constant rate intravenous infusion from early blood level (Barzegar-Jalali, 1981b) and urinary excretion data (Barzegar-Jalali, 1982a) as well as the advantage of the methods have been discussed. In this communication methods of obtaining the parameters of the linear two-compartment open model with constant intravenous infusion from early blood level data are presented. (a) The plasma concentration, C, of a drug with a linear two-compartment open model during a constant rate intravenous infusion is given by Eqn. 1: