Abstract
NOT ONLY does an extract of the adrenal cortex influence renal function and the distribution and excretion of electrolytes but, in addition, it has a marked effect on carbohydrate metabolism (1). No single method can be used to determine the potency of an extract of the adrenal cortex in regard to both renal function and carbohydrate metabolism. For bioassay of the influence on the kidney the determination of changes of the concentration of urea in the blood of the adrenalec tomised dog has been shown to be satisfactory (1, 2) but no procedure for the bioassay of the potency of an extract of the adrenal cortex in respect to carbohydrate metabolism has been widely accepted. Since such a method would be of great assistance, particularly for standardization of preparations used in clinical medicine, we have carried out an investigation directed toward this objective.
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