Abstract
It is now well established that the numerous physiological disturbances resulting from adrenalectomy include a marked inhibition of lactation (see reviews by Turner [1939], Folley [1940] and Petersen [1944]). In a previous study of replacement therapy in adrenalectomized lactating rats [Folley & Cowie, 1944] we have shown that in our rats and under the conditions of our experiments, deoxycorticosterone acetate was more effective in maintaining lactation than either 11-dehydrocorticosterone or 17-hydroxy-11-dehydrocorticosterone. Neither with the steroid nor an extract of adrenal cortex, however, did we find it possible, with the doses given, to achieve complete restoration of lactation as judged by the only available criterion, the growth rates of litters of standard size measured under strictly controlled conditions. Our results differed from those of Gaunt, Eversole & Kendall [1942] who obtained normal lactation in adrenalectomized rats treated with 17-hydroxy-1 1-dehydrocorticosterone or with an extract of adrenal cortex, but only partial and
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