Abstract
An Easy, sensitive, specific and precise UPLC method for the pharmaceutical dose estimation of Remdesivir in tablet dosage form. Chromatogram was run through BEH (2.1 x 50mm, 1.7µm) Mobile phase containing 0.01N Kh2po4: Acetonitrile taken in the ratio 60:40 was pumped through column at a flow rate of 0.3ml/min. Buffer used in this method was 0.01N Potassium dihydrogen phosphate buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 252.0nm. Retention time of Remdesivir were found to be 1.565 min. %RSD of the Remdesivir were and found to be 0.3. %RSD of Repeatably precision of Remdesivir were found to be 0.3. %Recovery was obtained as 99.87% for Remdesivir. %Assay was obtained as 99.58% for Remdesivir. LOD, LOQ values obtained from regression equation of Remdesivir were 0.33, 1.00. Regression equation of Remdesivir is y = 22602x + 1936. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
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