Abstract
These three neuropeptides were measured at daily baseline values by radioimmunoassay. Stimulated parotid saliva was collected from 31 subjects using a modified Carlson-Crittenden device affixed over Stenson's duct. Methionine enkephalin-like immunoreactivity ranged from 6.6 to 11.7 fmol/ml, with a mean of 9.3 fmol/ml. Substance P-like immunoreactivity ranged from 6.1 to 12.6 fmol/ml, with a mean of 9.3 fmol/ml. β-Endorphin-like immunoreactivity ranged from 1.2 to 3.6 fmol/ml, with a mean of 2.6 fmol/ml. This is believed to be the first documentation of methionine enkephelin- and substance P-like activities in human parotid saliva and the first demonstration of β-endorphin-like activity in any type of human saliva. Substance P-like activity was significantly higher in morning than evening samples; β-endorphin-like activity also tended to be higher in the morning samples. Substance P and β-endorphinlike immunoreactivities covaried in a significant positive manner, suggesting either common control mechanisms or similar responses to physiological variables.
Published Version
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