Methanolic seed extract of Swietenia mahagoni: Evaluation of antimicrobial, antioxidant, and in-vivo toxicity assessment in the brine shrimp model

Abstract

In light of the availability of phytochemicals with medicinal properties, herbal remedies are a valuable natural resource. Sweetenia mahagoni has been used for centuries in tropical places for a variety of medical purposes. Preclinical studies are essential; therefore, it is important to confirm their safety and answer any lingering doubts about their efficacy before they enter human trials. Methanol was employed to macerate the plant and get out its phytochemical constituents. The presence of antimicrobial properties of the extract was demonstrated through in vitro studies of antibacterial activity against Gram-negative bacteria such as Escherichia coli and Salmonella abony. It’s possible that the extract can neutralize reactive oxygen species. Bioactive phytochemicals (limonoids, flavonoids, and terpenoids) have been linked to both antibacterial and antioxidant capabilities, according to trials testing their efficacy. The extract was found to be nontoxic to brine shrimp at concentrations up to 300 µg/mL in an in vivo lethality test.