Abstract
Acacia nilotica Linn commonly known as Babul is a multipurpose tree. As the world is turning back towards the herbal drug, it is the need of the hour to re-evaluate the knowledge of traditional medicine through vast review. In the Unani traditional system of medicine, all parts of the plant have been used as a remedy for various diseases and are imputed for their medicinal properties. Hence, this review presents an overview of the medicinal properties of different parts of A. nilotica L. used in Unani medicine, its phytochemical constituents, and diverse pharmacological activities. The information related to this drug was retrieved using the classical Unani sources viz., Al-Qanun fi’l Tibb (Canon of Medicine), Iksir-i-A‘zam, Al Hawi fi’l Tibb (Continens Liber), Tarjuma Kamil al-Sana‘a al-Tibbiyya, Dhakhira Khawarizm Shahi, Biyaz-i-Kabir and Tibb-i-Akbar for medicinal properties used in Unani Medicine. Further for other traditional uses, phytoconstituents and pharmacological activities, different search engines like PubMed, Medline, Google Scholar, Ovid, Science Direct and Scopus were also browsed.
 A. nilotica possesses various medicinal properties as per classical Unani texts such as astringent, tonic, wound healing, aphrodisiac, expectorant, resolvent, and antispasmodic. In vivo, in vitro, and clinical studies from the published articles validate the fact that A. nilotica is a potential source of various bioactive compounds having various pharmacological properties and therapeutic uses. The various pharmacological activities are anti-inflammatory, analgesic, antibacterial, anticancerous, antidiabetic and antihypertensive properties. This review concludes that the Unani medicinal effects of A. nilotica are proven by scientific studies.
Highlights
Medicinal plants have a long history of use for the benefit of mankind
Acacia nilotica Linn commonly known as Babul and Kikar has been used in Unani and other Indian System of Medicine for hundreds of years for the prevention and treatment of various health ailments
Earlier traditional description confirmed that A. nilotica has a rich amount of nutrients and contains a high therapeutic value which is capable of prevention, mitigation, and treatment of various infectious diseases and deleterious conditions [6]
Summary
Medicinal plants have a long history of use for the benefit of mankind. According to the report of the World Health Organization An in vitro study was undertaken to evaluate the hypoglycemic activity of roasted A. nilotica powder in diabetic rats, statistically significant lowering of blood glucose levels from 132.23±26.68 to 106.1±10.92 was observed [63] Another important study suggested that aqueous and methanol leaves extracts of A. nilotica exhibited hypoglycemic and anti-platelet aggregation activity in the streptozotocin-induced diabetic rats [64]. Another study showed that methanol extract of A. nilotica pods had antihypertensive and antispasmodic activity [32] It inhibited K+induced contraction in rabbit jejunum and suggested the antispasmodic action of A. nilotica, which was mediated through the calcium channel blockade, be responsible for the blood pressure-lowering effect of A. nilotica observed in the in vivo studies [66]. Effect of Abzan of Samar Babool in Sayalan al-Rahim-A randomized controlled study
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