Abstract
Hidrogels are three-dimensional networks with excellent hydrophilic characteristics, which mimic the EMC of the soft tissues and make them interesting materials for tissues regeneration. In this paper, methacrylated collagen/chitosan - based hydrogels, crosslinked with poly(ethylene glycol) diacrylate have been prepared and characterized in order to be used as scaffolds for soft tissue engineering. The three-dimensional structure, high hydrophilicity and macroporosity are characteristics that recommend these hydrogels for tissue regeneration. The synthetic polymer reacted with methacrylated collagen and methacrylated chitosan causing a significant increase pore diameter which is suitable for cell growth and proliferation. The biodegradation studies have shown that hydrogel scaffolds are susceptible to enzymatic attack under simulated physiological conditions of pH and temperature and the cytocompatibility tests indicate good cell-material interactions with fibroblasts.
Published Version
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