Metformin has increased efficacy under obese conditions in a novel genetically engineered mouse model of serous ovarian cancer

Abstract

respectively). A marked chemoprotective effect was observed with frequent, long-term use of both aspirin (OR 0.48, 95% CI 0.24–0.95, P = 0.04) and acetaminophen (OR 0.19, 95% CI 0.05–0.82, P= 0.03). Conclusions: Our findings indicate that frequent use of aspirin and acetaminophen for 5 or more years reduces the risk of cervical cancer, supporting their role in cancer prevention. The chemoprotective role of analgesics in cervical cancer opens new venue for future research elucidatingmolecular bases of carcinogenesis. Given thewidespreaduse of NSAIDs and acetaminophen worldwide, further investigation in a larger sample size with better-defined dosing regimens is warranted. Taking into account the existing data on the role of chronic inflammation in persistent high-risk HPV infection, future efforts should focus on primary and secondary prevention of cervical dysplasia.