Abstract
Metaplastic Breast Carcinoma (MBC) is very rare, and metaplastic carcinoma with osseous differentiation is even rarer. Here we report a case of metaplastic breast carcinoma with extensive osseous differentiation. A 65 years female presented with the complaint of lump left breast for the last 6 months. Fine Needle Aspiration Cytology (FNAC) suggested carcinoma breast. Modified radical mastectomy was performed. Histopathologically, the neoplasm consisted of invasive ductal carcinoma of no special type with an osseous metaplastic component and showed a direct transition from carcinoma to the osseous elements. It is necessary to distinguish the different types of metaplastic carcinomas and distinction between benign and malignant metaplastic (osteoid) elements should be taken into consideration.
Highlights
Metaplastic Breast Carcinoma (MBC) is a rare and histologically diverse subtype of breast carcinoma. It accounts for less than 1% of all breast cancers.[1,2]. It comprises a heterogeneous group of neoplasms characterized by an intimate admixture of adenocarcinoma with areas of spindle, squamous, chondroid, and osseous differentiation.[3]
Breast cancer with cartilaginous and/ or osseous metaplasia is a special type of invasive breast cancer and has been reported to occur in only 0.003-0.12% of breast cancer cases.[4]
We report a case of metaplastic breast carcinoma with extensive osseous differentiation and discuss the related literature
Summary
Metaplastic Breast Carcinoma (MBC) is a rare and histologically diverse subtype of breast carcinoma. We report a case of metaplastic breast carcinoma with extensive osseous differentiation and discuss the related literature
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