Abstract
The development of new nanomaterials with high biomedical performance and low toxicity is essential to obtain more efficient therapy and precise diagnostic tools and devices. Recently, scientists often face issues of balancing between positive therapeutic effects of metal oxide nanoparticles and their toxic side effects. In this review, considering metal oxide nanoparticles as important technological and biomedical materials, the authors provide a comprehensive review of researches on metal oxide nanoparticles, their nanoscale physicochemical properties, defining specific applications in the various fields of nanomedicine. Authors discuss the recent development of metal oxide nanoparticles that were employed as biomedical materials in tissue therapy, immunotherapy, diagnosis, dentistry, regenerative medicine, wound healing and biosensing platforms. Besides, their antimicrobial, antifungal, antiviral properties along with biotoxicology were debated in detail. The significant breakthroughs in the field of nanobiomedicine have emerged in areas and numbers predicting tremendous application potential and enormous market value for metal oxide nanoparticles.
Highlights
Progress in nanotechnology and interdisciplinary research enables the production of nanosized materials with unique physical and chemical properties that make them suitable candidates for biomedical applications
The results indicated that CPR, pro-inflammatory IL-1α and ADMA levels increase meaningfully concomitant with a reduction in NO level in the diabetic rats while ZnO
The primary goal of this review was to set a reference to researchers who are interested in nanoparticle-based functional biomedical applications
Summary
Progress in nanotechnology and interdisciplinary research enables the production of nanosized materials with unique physical and chemical properties that make them suitable candidates for biomedical applications. Nanotechnology includes synthesis and control of matter at dimensions of a few hundred nanometers that enable specific size-dependent properties [1]. Nanoparticles (NPs) dedicated to nanomedical applications ought to have a preferential size of less than 200 nm [2]. Zero-dimensional nanomaterials include NPs, nanoclusters, quantum dots and so forth that have all dimensions on the nanometer scale. For the synthesis of these MONPs, various methods have been have been introduced that are summarized in previous reviews [6]. MONPs have highly ionic introduced that are summarized in previous reviews [6]. MONPs have highly ionic nature nature and can be organized with crystal morphologies exhibiting various reactive sites and corners.
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