Metal Nanoparticles for Ovarian Cancer Therapy

Abstract

Background: Ovarian cancer is the most fatal gynecological cancer, with the highest death rate because of its late diagnosis and recurrence. Owing to the inherent drawbacks of conventionally available approaches for ovarian cancer treatment, alternative strategies need to be developed. Recently, nanotechnology-based drug delivery vehicles (polymer, liposome, dendrimers, etc.) have been extensively used in cancer therapy, especially for ovarian cancer. Among various nanoformulations, metal nanoparticle-based approaches are widely studied for ovarian cancer treatment as they offer several advantages, such as high therapeutic output, biocompatibility, non-toxicity, non-inflammatory effects, biodegradability, etc. Objective: This review aimed to emphasize the advancement of metal-based nanoformulations for ovarían cancer therapy along with toxicological aspects. Methods: The information was gathered from many search engines, such as SciFinder, PubMed, and ScienceDirect, to get coverage of suitable research and compile relevant data about metal nanoparticles for ovarian cancer treatment. Results: Investigating metal nanoparticle-based therapies for the treatment of ovarian cancer provides a new direction for future studies. Conclusion: This review highlights the anti-cancer activity of metal nanoformulations for ovarian cancer therapy, recent progress, challenges, and future perspectives in detail, along with the toxicological aspects.