Abstract
Metal ion chelators combined with nanostructure materials proved effective in the treatment and diagnosis of human diseases. Combine potentiometry, EPR and NMR techniques determine ligand content, metal complex stability constants and competition between metallodrugs and endogenous molecules. More details can be found in article number 2000544 by Joanna Izabela Lachowicz, Mariusz Jaremko, and co-workers.
Highlights
SBA-TETA is a mesoporous material functionalized with TETA copper and zinc chelating agent
SBA-TETA joins versatility of mesoporous materials to load a large amount of cargo, environmental-friendly, and bioavailability, with TETA high efficiency in metal coordination
Potentiometry technique was used for the first time for ligand content quantification in the SBA-TETA material and for the determination of metal complex formation constants
Summary
Pluronic copolymer P123 (EO20PO70EO20) tetraethylorthosilicate, TEOS (≥99%); (3-chloropropyl)trimethoxysilane, CPTMS (≥97%); triethylenetetramine, TETA (≥97%); copper chloride dihydrate, CuCl2∙2H2O (≥99.0%), ZnCl2 (≥99.0%) anhydrous toluene (≥99.7%), dimethylformamide (DMF, ≥99.9%), acetone (≥99%), HCl (37%), NaCl, NaOH pellets were purchased from Sigma-Aldrich (Milano, Italy). Copper (1000 ± 2 ppm in HNO3 2% m/m) and zinc (1000 ± 2 ppm in HNO3 1% m/m) stock solutions were purchased from Fluka Analytical and Aldrich Chemical Company, respectively. Diethyl ether (99.8%), and ethanol (99.8%) were purchased from Honeywell
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