Metal complexes of alkylating agents. V. Complexes of phosphoramide mustard derivatives

Abstract

Metal complexes of phosphoramide mustard derivatives of RR′P(O)N(CH 2CH 2Cl) 2 where R  R′  NH 2 (L 1); R  OP(R′)(O)N(CH 2CH 2Cl) 2 and R′  N(CH 3) 2 (L 2) have been prepared. The L 2 ligand is a novel organophosphorus compound. Metal complexes of L 1 include M(ClO 4) n (L 1) x where n = 2, x = 4, M  Cu, Mg; n = 2, x = 5, M  Co, Ni; n = 3, x = 5, M  Al; n = 2, x = 6, M  Ba, Mn; and MCl 2(L 1) x where x = 3, M  Co; x = 4, M  Cu. Metal complexes of L 2 include M(ClO 4) x (L 2) x (H 2O) y where x = 2, M  Ba, Co, Cu, Mg, Mn, Ni; x = 3, M  Al, La and y = 2, 4, 6 or 8. Nickel(II) and cobalt(II) complexes of trimethyl phosphonoacetate (TMPA) with stoichiometry Ni(TMPA) 2(ClO 4) 2·3H 2O and Co(TMPA) 2(ClO 4) 2·2H 2O have also been prepared.