Abstract
Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency. Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly metal complexes have played an important role in the development of new metal based drugs. A significantly rising interest in the design of metal complexes as drugs and diagnostic agents is currently observed in the area of scientific inquiry, specifically termed medicinal inorganic chemistry. In this review our main focused on research undertaken over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-inflammatory, anti-cancer, DNA- interaction and anti-tumor action of synthetic metal complexes.
Highlights
Metal ions play important roles in biological processes and the field of knowledge concerned with the application of inorganic chemistry to therapy or diagnosis of disease is medicinal inorganic chemistry [1]
The results showed that steroidal complexes are better inhibitors of both types of the bacteria (Gram-positive and Gram-negative) as compared to steroidal thiosemicarbazones [79]
Mixed ligand copper(II) complexes containing derivatives of salicylic acid and heterocyclic ligands with nitrogen donor atoms have been prepared by Lenka Kuckova and et al The derivatives of salicylic acids in the coordination environment of copper(II) complexes are responsible for radicals scavenging activity, incorporation of chelating ligand 2,9-dimethyl-1,10-phenantroline into the copper(II) complexes significantly enhances their capability of binding to DNA via intercalation [103]
Summary
Metal ions play important roles in biological processes and the field of knowledge concerned with the application of inorganic chemistry to therapy or diagnosis of disease is medicinal inorganic chemistry [1]. Md. Saddam Hossain et al.: Metal Complexes as Potential Antimicrobial Agent: A Review the attention is focused primarily on the research concerning with a few pharmacological activities of the cheaper and available first-row transition metal coordination compounds V(IV), V(II), Cr(III), Mn(II), Fe(II) and Co(II) complexes. Saddam Hossain et al.: Metal Complexes as Potential Antimicrobial Agent: A Review the attention is focused primarily on the research concerning with a few pharmacological activities of the cheaper and available first-row transition metal coordination compounds V(IV), V(II), Cr(III), Mn(II), Fe(II) and Co(II) complexes These metal ions are the essential elements present in the biological intracellular environment of living organisms. In this paper we have explored the overview of important application of metal complexes in medicine and drugs
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