Abstract
Antibiotic resistance has been growing at an anxious rate and as a result the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia, growth retardation, heart disease in infants etc. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly Mn metal complexes have played an important role in the development of new metal based drugs. Over the past few years, there have been many reports on their applications in homogeneous and heterogeneous catalysis. The activity is usually increased by complexation therefore to understand the properties of both ligands and metal can lead to the synthesis of highly active compounds. The influence of certain metals on the biological activity of these compounds and their intrinsic chemical interest as multidentate ligands has prompted a considerable increase in the study of their coordination behavior. Development of a new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. In this review we have focused on research of Mn complexes incorporation of Schiff bases carry out over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-tuberculosis, anti-inflammatory, anti-cancer, DNA- interaction and anti-tumor action of synthetic metal complexes.
Highlights
Interest in the study of Schiff base hydrazones has been growing because of their antimicrobial, anti-tuberculosis, and anti-tumour activity [1,2,3,4,5,6,7,8,9,10,11,12]
Schiff bases play an important role in inorganic chemistry, as they form stable complexes with most transition metal ions
The development of the field of bioinorganic chemistry has increased the interest in Schiff base complexes, since it has been recognized that many of these complexes may serve as models for biologically important species [1,2,3,4,5]
Summary
Interest in the study of Schiff base hydrazones has been growing because of their antimicrobial, anti-tuberculosis, and anti-tumour activity [1,2,3,4,5,6,7,8,9,10,11,12]. Schiff bases play an important role in inorganic chemistry, as they form stable complexes with most transition metal ions. The diameter of the clear zone of inhibition surrounding the sample is taken as a measure of the inhibitory power of the sample against the particular test organism This may be due to that the chelation considerably reduces the polarity of the metal ion mainly because of partial sharing of its positive charge with the donor groups and possible electron delocalization over the whole created ring such, chelation could enhance the lipophilic character of the central metal atom, which subsequently favors its permeation through the lipid layer of the cell membrane [35]. Metal complexes of these ligands exhibited very slight increase in antifungal activities [36]
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