Abstract
The α-hydroxyacid 2-hydroxy-4-methylthiobutanoic acid (the so-called methionine hydroxy-analogue, MHA), largely used in animal nutrition as a source of methionine, forms stable metal chelates with divalent metals of formula [{CH 3SCH 2CH 2CH(OH)COO} 2M]· nH 2O. Protonation and zinc(II) complex formation constants have been determined by pH-metry at 25 °C; the ternary system Zn 2+/MHA/glycine was also studied by pH-metry and the formation constant of the species [ZnLA] was determined [log β=6.57(11)]. Experiments in vitro with human intestinal CACO-2 cells indicated that the MHA/Fe chelate was taken up by the cells without any apparent toxic effect.
Published Version
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