Abstract
Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine and characterize putative biomarkers that predict the laxative effects induced by RLP treatment, alteration of endogenous metabolites was measured in the serum of loperamide (Lop)-induced constipation rats after administration of RLP extract (EtRLP) using 1H nuclear magnetic resonance (1H NMR) spectral data. The urine volume and amounts, and weights and water contents of stools were significantly recovered in the Lop + EtRLP treated group as compared to the No group, whereas body weight and food intake maintained constant levels. Also, significant recoveries in the thickness of mucosa and muscle were detected in the colon of the Lop + EtRLP treated group. Furthermore, pattern recognition showed absolutely different clustering of the serum analysis parameters when comparing the Lop treated group and Lop + EtRLP treated group. Of the 33 endogenous metabolites, 7 amino acids (alanine, arginine, glutamate, glutamine, glycine, threonine and valine) and 8 endogenous metabolites (betaine, creatine, glucose, taurine, ethanol, lactate, glycerol and succinate) were dramatically increased in the Lop + EtRLP treated SD rats. These results provide the first evidence pertaining to metabolic changes in the constipation rats treated with Lop + EtRLP. Additionally, these findings correlate with changes observed in 15 metabolites during the laxative effects of EtRLP.
Highlights
Constipation is a bowel disease characterized by symptoms such as infrequent bowel movements, difficulty during defecation, and sensation of incomplete bowel evacuation [1,2,3,4]
Effect of EtRLP on the feeding behavior and excretion parameters of the constipation rats To investigate whether EtRLP treatment affects the feeding behavior and excretion parameters of constipated rats, we measured the food intake, water consumption and excretion parameters in SD rats of subset groups
These results indicate that EtRLP treatment improves the excretion parameters of Lop-induced constipation in SD rats without any changes in the feeding behavior
Summary
Constipation is a bowel disease characterized by symptoms such as infrequent bowel movements, difficulty during defecation, and sensation of incomplete bowel evacuation [1,2,3,4]. This disease is often the outcome of numerous reasons including insufficient dietary fiber intake, inadequate fluid intake, decreased physical activity, side effects of medication, hypothyroidism, obstruction by colorectal cancer, and side effects due to drug (2019) 35:9 constipation, a recent study has investigated the therapeutic effects of Red Liriope platyphylla extract (EtRLP) in Lopinduced constipated SD rats [12]. To date, there has been no research in screening of metabolomics biomarkers that anticipate the laxative effects induced by RLP treatment
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