Metabolomic studies for medicinal plant raw materials

Abstract

Every year, medicinal plant raw materials are increasingly found in the production of medicines. Despite a number of positive properties of plants and raw materials obtained from them, there are also negative aspects of the introduction of native (natural) drugs. For example, biological active substances, their quantity and activity, depend on the season of the year and the climatic conditions of the region. These factors are highly variable, and correlations of biologically active substances with weather are difficult to predict. Thus, only with the help of modern analytical instruments and validated methods can it be possible to create statistically reliable algorithms for searching for biologically active substances.The polythematic abstract and bibliographic database has been analyzed. The main attention was paid to such scientometric databases as: Web of Science Core Collection, Medline, PubMed, RSCI, as well as data from the eLIBRARY.ru portal over the past 10 years. An assessment was made of the statistical data and publication activity of the authors regarding the request for metabolomics of medicinal plant raw materials in medicine and veterinary medicine.Metabolomic studies of medicinal plants aim to provide a complete and accurate study of all small molecule metabolites and complement other omics technologies such as genomics, transcriptomics and proteomics.Based on the literature reviewed, it can be concluded that there are two main approaches to collecting metabolomic data: targeted and untargeted analysis. Targeted and untargeted metabolomics analyzes are similar in sample collection, preparation, and chromatographic conditions (stationary phase and mobile phase). However, targeted metabolomics studies mainly focus on multiple metabolites from the same or different pathways.