Abstract
Homogenized gastric, duodenal and ileal mucosa samples from adult male humans were incubated with [4- 14C]-testosterone or [4- 14C]-androstenedione. In addition soluble fractions of adult male human gastric or intestinal mucosa were incubated with [4- 14C]-testosterone. Intestinal homogenates from several human fetuses of both sexes (crown-heel lengths 50–210 mm) were incubated either with [4- 14C]-testosterone or [4- 14C]-androstenedione. Only 5α-reduced metabolites could be detected after adult homogenate incubations and only 5β-reduced forms after soluble fraction incubations. The fetal intestines showed great interindividual variation and produced either 5α-metabolites or both 5α- and 5⨿-metabolites. Quantitatively, on tissue weight basis, the smallest fetuses metabolized testosterone and androstenedione with a capacity at least equal to the oldest ones. With adult intestinal homogenates the metabolism seemed to increase towards the aboral direction of the gastrointestinal tract.
Published Version
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