Abstract
Metabolic profiles of renal arteriolar smooth muscle cells were constructed from semiquantitative histochemical analysis of biopsies from 20 mongrel dogs. Vessels ranging in outer wall diameter from 20 to 80 μm were analyzed for the presence and relative intensity of 14 enzymes and 3 substrates with attention being directed in particular to arteriolar smooth muscle cells. Enzymes representing glycolysis, the Krebs cycle, the hexose monophosphate shunt, lipid metabolism, the respiratory chain, and ATP hydrolysis were chosen. Glycogen, hydrophobic lipid, and free fatty acids were also studied. Renal arteriolar cells appear to be chiefly oxidative in their metabolism with a possible preference for free fatty acids as substrate. Anaerobic metabolism seems rather limited in these cells. Finally, arteriolar smooth muscle was found to be quite rich in myosin ATPase.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call