Abstract
Phosphatidylcholine (PC) is the most abundant phospholipid in pancreatic islets. “De novo” synthesis of islet PC has been shown to be enhanced by glucose1 and PC is degredated during glucose stimulation of insulin secretion2 thus implicating PC turnover as a regulatory event in glucose-induced insulin secretion. The aim of the present investigation was to evaluate the effect of insulin secretagogues on degradation of islet PC as measured by the formation of water soluble choline-containing metabolites of PC in mouse pancreatic islets.
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