Abstract
Ketogenesis from extracellular substrates was quantified using intact rat hepatocytes. Rates of ketogenesis from octanoylcarnitine and palmitoylcarnitine were 20 and 30%, respectively, of the rates observed from the corresponding free acids. In contrast, the free acids and the acylcarnitines were converted to ketone bodies at similar rates in a liver homogenate system. These results suggest that medium- and long-chain acylcarnitines may be relatively poor substrates for metabolism by intact liver cells.
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