Abstract
ω-and (ω-1)-Oxidation of secobarbital was studied with cell free systems of rabbit liver. By gas chromatography, secobarbital was found to be metabolized into (ω-1)-hydroxy-secobarbital, ω-carboxysecobarbital, and (ω-1)-oxosecobarbital by incubation with 9000g supernatant fraction of liver homogenate. When secobarbital was incubated with microsomes with addition of NADPH and oxygen, formation of (ω-1)-hydroxysecobarbital and (ω-1)-hydroxymethylhexabital dehydrogenase were not concerned with metabolism of secobarbital in rabbit liver.
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