Abstract
17-Hydroxyprogesterone-6,7-H 3 (17-OHP) was administered intravenously to three male and two female chimpanzees. Forty-four per cent of the dose of 17-OHP was recovered in the urine in 48 hours. Thirty-four per cent of the dose was extracted from the urine as unconjugated and glucuronidase-hydrolyzed metabolites. One per cent of the dose was recovered as sulfates. The ratio of unconjugated metabolites to glucosiduronates varied from 7:3 to 9:1. An average of 8% of the dose of 17-OHP consisted of pregnanetriol-3α,17α,20α (P-triol) and 8% of 3α,17α-dihydroxypregnane-20-one (P-diolone). Of the urinary radioactivity, 17% was present as P-triol, 18% as P-diolone. P-triol accounted for 23% and P-diolone 24% of the radioactivity in the neutral extracts. Except for the high proportions of unconjugated metabolites in chimpanzee urine, their metabolism of 17-OHP was similar to the metabolism of 17-OHP in human beings.
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