Abstract
Tracer doses of progesterone-4-C 14 were administered to four male and two female immature chimpanzees. An average of 28% of the radioactive dose was recovered in the urine in 48 hours. Twenty per cent of the dose of progesterone was extracted as unconjugated and glucuronidase-hydrolyzed metabolites of which the greater proportion was in the unconjugated form. An average of 7% of the dose of progesterone was recovered as pregnanediol-3α,20α, which accounted for 33% of the radioactivity in the neutral extracts. Except for the high proportion of unconjugated metabolites in the chimpanzees, the metabolism of progesterone was very similar to that observed for men.
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