Metabolik Sendrom Komponentleri ve Psoriatik Artrit Ürik Asit Seviyelerini Etkiler mi?

Abstract

Objective: Hyperuricemia is common in psoriatic arthritis (PsA). The aim of this study is to investigate the effect of PsA and metabolic syndrome (MS) components on serum uric acid (SUA). Material and Methods: A total of 102 adult individuals (53 females and 49 males) participated in this study. Fifty-one consecutive PsA patients followed and treated in the outpatient clinic between April 2011 and 2012 were enrolled in this study retrospectively. The control group consisted of 51 patients who have arthralgia but not arthritis. Insulin resistance was calculated according to the homeostasis model of assessment insulin resistance (HOMA-IR) formula. Patients were classified as having MS according to the National Cholesterol Education Program/Adult Treatment Panel definition. Results: SUA levels were higher in MS (p=0.016), but when adjusted for age, this difference was not found to be statistically significant. It was found that hypertension (HT), triglyceride (TG) and HOMA-IR which are important components of MS had an effect on SUA level but the effect of PsA on SUA was not found. SUA level was higher in patients with HT, TG and HOMA-IR elevation than those without (respectively, p=0.009, p=0.005, p=0.001). It was observed that PsA had no effect on SUA, but when adjusted for age, the UA level in PsA was found to be significantly higher (p=0.027). Conclusion: MS, which is a major risk factor for atherosclerosis, is increased in PsA. However, this increase may also be associated with higher age in PsA patients. It is known that there is a relationship between cardiovascular events and high SUA levels. SUA is known to play a potential role as a risk factor for atherosclerosis and related diseases. More studies are needed to investigate the effects of PsA and MS components on SUA levels.