Abstract
BackgroundElevated triglyceride (TG) levels are a biomarker for cardiovascular disease (CVD) risk. The correlation between serum uric acid (SUA) and TG concentrations in adults or obese children is well established. However, studies on SUA and TG in children with short stature are limited.AimTo determine the relationship between SUA and TG levels in short children and adolescents.MethodThis was a cross-sectional evaluation of a cohort of 1095 patients with short stature (720 males and 375 females). The related clinical characteristics, including anthropometric and biochemical parameters, were determined.ResultsSmooth curve fitting, adjusted for potential confounders was performed, which indicated the existence of a non-linear relationship between these measures. Piecewise multivariate linear analysis revealed a significant positive relationship between SUA and TG at SUA concentrations over 7 mg/dL (β = 0.13, 95% CI: 0.05–0.22, P = 0.002) but no significant correlation at lower SUA levels (β = 0.01, 95% CI: 0.01–0.04, P = 0.799). Furthermore, a stratified analysis was performed to appraise changes in this relationship for different sexes and standard deviation levels of body mass index (BMI). The non-linear relationship remained consistent in males and females with BMI standard deviation scores (BMI SDS) ≥ 0, with inflection points of 6.71 mg/dL and 3.93 mg/dL, respectively. Within these two groups, SUA and TG levels showed a positive association when SUA levels were higher than the inflection point (β = 0.21, 95% CI: 0.11–0.31, P < 0.001 for males and β = 0.1, 95% CI: 0.03–0.17, P = 0.005 for females). However, a specific relationship was not observed at lower SUA levels. No significant relationships were found between SUA and TG levels in males and females with BMI SDS < 0.ConclusionThe present study identified the non-linear association of SUA and TG levels with short children and adolescents. This relationship was based on BMI status. This finding suggests that health status should be considered for short stature children with high SUA levels, especially in children with a high BMI standard deviation score.
Highlights
Elevated triglyceride (TG) levels are a biomarker for cardiovascular disease (CVD) risk
The non-linear relationship remained consistent in males and females with body mass index (BMI) standard deviation scores (BMI Insulin like growth factor-1 standard deviation scores (SDS)) ≥ 0, with inflection points of 6.71 mg/dL and 3.93 mg/dL, respectively
serum uric acid (SUA) and TG levels showed a positive association when SUA levels were higher than the inflection point (β = 0.21, 95% CI: 0.11–0.31, P < 0.001 for males and β = 0.1, 95% CI: 0.03–0.17, P = 0.005 for females)
Summary
Elevated triglyceride (TG) levels are a biomarker for cardiovascular disease (CVD) risk. Studies on SUA and TG in children with short stature are limited. Findings in previous prospective studies and meta-analyses showed the probability of an existing negative correlation between height and cardiovascular disease (CVD) risk [3,4,5,6]. This probability of a negative association exists between height and lipid levels for both children and adults [7,8,9]. It is necessary to pay attention to the lipid profile of short children as a risk factor for CVD. CVD is not very common in young people, the accumulation of intimal fat streaks is an early form of atherosclerosis that accompanies dyslipidaemia in childhood [10,11,12]
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