Abstract

IntroductionThere is a remarkable increase in cardiovascular disease after menopause. On the other hand, metabolic syndrome as a collection of risk factors has a known effect on cardiovascular diseases. Hormone changes are considered as one of the main relevant factor regarding cardiovascular disease as well as some recognized relationship with metabolic syndrome's components. This study was carried out in order to search for prevalence of metabolic syndrome during menopausal transition.MethodIn a cross sectional study in urban and rural areas of Isfahan, Najafabad and Arak cities, 1596 women aged more than 45 years were investigated using Isfahan Healthy Heart Program's (IHHP) samples. Participants were categorized into three groups of pre-menopause, menopause and post-menopause. Leisure time physical activity and global dietary index were included as life style factors. The association of metabolic syndrome and its components with menopausal transition considering other factors such as age and life style was analyzed.Resultsthere were 303, 233 and 987 women in premenopausal, early menopausal and postmenopausal groups respectively. Metabolic syndrome was found in 136(44.9%) premenopausal participants and significantly increased to 135(57.9%) and 634(64.3%) in early menopausal and postmenopausal participants respectively, when age was considered (P = 0.010). Except for hypertension and hypertriglyceridemia, there was no significant difference between three groups of menopausal transition when metabolic syndrome's components were considered.ConclusionIn contrary to the claims regarding the role of waist circumference and blood glucose in increasing of metabolic syndrome during the menopausal transition, this study showed this phenomenon could be independence of them.

Highlights

  • There is a remarkable increase in cardiovascular disease after menopause

  • In contrary to the claims regarding the role of waist circumference and blood glucose in increasing of metabolic syndrome during the menopausal transition, this study showed this phenomenon could be independence of them

  • Considering the metabolic changes that occur in women during post menopause (PM), there is an increase in risk factors of cardiovascular diseases (CVD) and incidence of these diseases in PM [2]

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Summary

Introduction

There is a remarkable increase in cardiovascular disease after menopause. On the other hand, metabolic syndrome as a collection of risk factors has a known effect on cardiovascular diseases. Hormone changes are considered as one of the main relevant factor regarding cardiovascular disease as well as some recognized relationship with metabolic syndrome’s components. Considering the metabolic changes that occur in women during post menopause (PM), there is an increase in risk factors of cardiovascular diseases (CVD) and incidence of these diseases in PM [2]. Metabolic syndrome (MetS) is a cluster of components which make the individual susceptible to CVD. These components are: increased lipid accumulation in central parts of the body (abdominal obesity), insulin resistance (IR), dyslipidemia (elevated triglyceride and LDL and decreased HDL), and hypertension. Various studies have shown that being affected by MetS increases the risk of CVD as well as morbidity of the disease [6]

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