Association of Metabolic Syndrome with Asymptomatic Hyperuricemia in a Georgian Population

Abstract

Aim: The prevalence of hyperuricemia has been increased in recent years. The metabolic syndrome (MS), which consists of multiple interrelated conditions, increases the risk for atherosclerosis, cardiovascular diseases and type 2 diabetes, as well as mortality from cardiovascular diseases and all causes (1). Several studies have found an association between hyperuricemia and metabolic syndrome, moreover, several authors have suggested that serum uric acid (SUA) levels should be included in the definition of metabolic syndrome, as increased serum uric acid levels are independently associated with a higher risk of cardiovascular mortality. The aim of the present study was to analyze the association of hyperuricemia and metabolic syndrome and its several components in a Georgian population. The study include 83 patients with MS and hyperuricemia (51 males and 32 females), aged 61±9 years, who have addressed to The First University Clinic of Tbilisi State Medical University from January 2017 to December 2017. All patients had asymptomatic hyperuricemia. 55 patients without MS constituted the control group. Biochemical parameters: glucose, Total-Cholesterol, HDL-cholesterol, LDL-cholesterol, Triglycerides, Creatinine, Uric acid, C-reactive protein (CRP) were obtained with routine technique. Hyperuricemia was defined as SUA level ≥7.0 mg/dL in men and ≥6.0mg/dL in women. Waist circumference (cm) was measured and body mass index (BMI) was calculated (kg/m2). Results: The result of our study shows, that patients with MS show higher risk of hyperuricemia than those without MS – 7.8 ±2.1 vs 5.9±1.3. Hyperuricemia was associated with a higher risk of presenting all the MS components, except hypertension and HDL. Conclusion: In the present study carried out in a Georgian population, we have found an association between SUA levels and MS, especially with Glucose intolerance, abdominal obesity and hypertriglyceridemia.