Metabolic syndrome correlates intracoronary stenosis detected by multislice computed tomography in male subjects with sleep-disordered breathing

Tomoko Nakanishi-Minami,Koji Yanagi,Yasuhiko Nakagawa,Yoshiharu Nishida,Iichiro Shimomura,Ken Kishida,Munetaka Nishio,Tohru Funahashi,Ryoko Yoshida,Chisa Nakagawa

doi:10.1186/1758-5996-4-6

Tomoko Nakanishi-Minami, Koji Yanagi + Show 8 more

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https://doi.org/10.1186/1758-5996-4-6

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Abstract

BackgroundSleep-disordered breathing (SDB), especially obstructive sleep apnea (OSA), has frequent complications include hypertension, dyslipidemia and insulin resistance based on abdominal obesity or excess visceral fat (called Syndrome Z). OSA is a potential risk factor for cardiovascular diseases. The clinical characteristics of Japanese OSA subjects with OSA remain unclear. The present study investigated prevalence and predictive factors of intracoronary stenosis detected by multislice computed tomography (MSCT) in Japanese male subjects with SDB/OSA.FindingsThe study (O-VFStudy) subjects were 39 Japanese men with SDB/OSA who underwent all-night cardiorespiratory monitoring with fully attended polysomnography, and moreover both fat computed tomography (CT) scan and 64-row MSCT coronary angiography. The prevalence of coronary stenosis in this selected population with SDB/OSA was 15%. Logistic regression analysis showed a significant relationship between age-adjusted CAD and metabolic syndrome (p < 0.05), but not serum adiponectin levels and nocturnal fall in adiponectin. Subjects with the metabolic syndrome had significantly higher prevalence of CAD (31.3 versus 4.3%, p = 0.033), and lower levels of serum adiponectin (4.5 ± 0.6 versus 6.4 ± 0.6 μg/mL, p = 0.014), compared with groups without the metabolic syndrome.ConclusionsThe present study describes that the prevalence of greater than 50% intracoronary stenotic lesions detected by MSCT was 15% and the metabolic syndrome was correlated with intracoronary stenosis detected by MSCT in Japanese SDB/OSA subjects.Trial RegistrationUMIN 000002997https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000003633&language=E.

Highlights

Sleep-disordered breathing (SDB), especially obstructive sleep apnea (OSA), has frequent complications include hypertension, dyslipidemia and insulin resistance based on abdominal obesity or excess visceral fat
The present study describes that the prevalence of greater than 50% intracoronary stenotic lesions detected by multislice computed tomography (MSCT) was 15% and the metabolic syndrome was correlated with intracoronary stenosis detected by MSCT in Japanese SDB/OSA subjects
We have recently demonstrated that, 1) production of adiponectin is dysregulated in intra-abdominal obese patients with severe OSA [12,13], and 2) night-time onset of acute coronary syndrome is associated with excess visceral fat and SDB [14], which is called “Syndrome Z” [15]

Summary

Introduction

Sleep-disordered breathing (SDB), especially obstructive sleep apnea (OSA), has frequent complications include hypertension, dyslipidemia and insulin resistance based on abdominal obesity or excess visceral fat (called Syndrome Z). The present study investigated prevalence and predictive factors of intracoronary stenosis detected by multislice computed tomography (MSCT) in Japanese male subjects with SDB/OSA. Sleep-disordered breathing (SDB), especially obstructive sleep apnea (OSA), is a potential risk factor for cardiovascular diseases, including coronary artery disease (CAD) and stroke [1,2,3]. OSA is common in middle-age men [4], and frequent complications include syndrome is associated with excess visceral fat and SDB [14], which is called “Syndrome Z” [15]. The present study investigated prevalence and predictive factors of intracoronary stenosis detected by multislice computed tomography (MSCT) in Japanese male subjects with OSA

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