Is vaspin related to cardio-metabolic status and autonomic function in early stages of glucose intolerance and in metabolic syndrome?

Tsvetalina Tankova,Nevena Chakarova,Lilia Dakovska,Greta Grozeva,Georgi Kirilov,Rumyana Dimova

doi:10.1186/s13098-016-0165-1

Tsvetalina Tankova, Nevena Chakarova + Show 4 more

Open Access

https://doi.org/10.1186/s13098-016-0165-1

Copy DOI

Abstract

BackgroundThis study aims to assess serum vaspin in early stages of glucose intolerance and in the presence of metabolic syndrome (MetS); and to evaluate vaspin correlation to different cardio-metabolic parameters and autonomic tone in these subjects.Methods185 subjects (80 males and 105 females) of mean age 45.8 ± 11.6 years and mean BMI 31.2 ± 6.3 kg/m2, divided into groups according to: glucose tolerance, presence of MetS and cardio-vascular autonomic dysfunction (CAD), were enrolled. Glucose tolerance was studied during OGTT. Anthropometric indices, blood pressure, HbA1c, serum lipids, hsCRP, fasting immunoreactive insulin and serum vaspin were measured. Body composition was estimated by impedance analysis. AGEs were assessed by skin fluorescence. CAD was assessed by ANX-3.0.ResultsThere was no difference in vaspin levels between the groups according to glucose tolerance, presence of MetS, and CAD. Regression analysis revealed independent association between serum vaspin and total body fat in newly diagnosed type 2 diabetes (NDT2D) group, and between serum vaspin and age and total body fat in MetS group. Vaspin negatively correlated with both sympathetic and parasympathetic activity in normal glucose tolerance (NGT) and just with parasympathetic tone in NGT without MetS.ConclusionOur results demonstrate no overt fluctuations in vaspin levels in the early stages of glucose intolerance and in MetS. Total body fat seems to be related to vaspin levels in MetS and NDT2D. Our data show negative correlation between vaspin and autonomic function in NGT, as vaspin is associated with parasympathetic activity even in the absence of MetS.

Highlights

This study aims to assess serum vaspin in early stages of glucose intolerance and in the presence of metabolic syndrome (MetS); and to evaluate vaspin correlation to different cardio-metabolic parameters and autonomic tone in these subjects
The normal glucose tolerance (NGT) + MetS group showed a positive correlation between serum vaspin and age, and advanced glycation end products (AGEs), whilst in NGT–MetS group serum vaspin significantly correlated with age
Our results demonstrated no significant difference in vaspin levels between the groups according to glucose tolerance and the presence of MetS

Summary

Introduction

This study aims to assess serum vaspin in early stages of glucose intolerance and in the presence of metabolic syndrome (MetS); and to evaluate vaspin correlation to different cardio-metabolic parameters and autonomic tone in these subjects. Vaspin is a visceral adipose tissue (VAT)-derived serine protease inhibitor with insulin-sensitizing effects. It is found in the VAT of Otsuka Long-Evans Tokushima Fatty rat, an animal model with central obesity and type 2 diabetes (T2D) [1]. A meta-analysis, encompassing six studies including 1826 obese individuals and 11 studies including 1570 subjects with T2D has been conducted It provides evidence of higher vaspin levels in obesity and T2D and emphasizes the pivotal role of vaspin in the progression of metabolic and glucose abnormalities [4]. The results of a growing number of studies in different ethnic groups have shown that cardiovascular autonomic dysfunction (CAD) is present in the early stages of abnormal glucose homeostasis [5, 6] and suggested its multifactorial modality and its relation to a number of cardio-metabolic risk factors. Central obesity is a confirmed risk marker for CAD [7], probably due to increased adipokine synthesis and secretion from VAT

Objectives

Results

Discussion

Conclusion