Abstract
Metabolic Studies in Brain Slices – Past, Present, and Future
Highlights
Metabolic brain slice studies were initiated by Warburg et al (1924)
In 13C-NMR studies, using labeled glucose and the astrocyte-specific substrate acetate, Badar-Goffer et al (1992) concluded that the high K+-mediated increase in O2 consumption occurred in glial cells
In awake rats total pyruvate fluxes after glycolytic conversion of glucose to pyruvate followed by pyruvate dehydrogenase (PDH-) mediated) entry into the TCA cycle together with flux mediated by the astrocyte-specific pyruvate carboxylase (PC) amount to ∼1.67 μmol/min/g wet wt (Öz et al, 2004; Table 1)
Summary
Metabolic brain slice studies were initiated by Warburg et al (1924). During the 1930s several such studies showed lactate release to incubation media and stimulation of respiration by high K+ concentrations, initially by ∼65% (Ashford and Dixon, 1935; Dickens and Greville, 1935). Metabolic brain slice studies were initiated by Warburg et al (1924). During the 1930s several such studies showed lactate release to incubation media and stimulation of respiration by high K+ concentrations, initially by ∼65% (Ashford and Dixon, 1935; Dickens and Greville, 1935).
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