Metabolic regulation of immune responses: new perspective for sepsis research

Abstract

Immune metabolism is an emerging highlight in recent years. Revealing the metabolic characteristics of different immune cells in different responses may provide new perspective and direction for the pathogenesis and therapy of many immune-related diseases. Sepsis is a complex systemic inflammation caused by trauma, infection and other pathogenic factors. The immune cells have different metabolic features at different stages of the disease. These metabolic features are also involved in the regulation of immune cell proliferation, differentiation and function. By summarizing and analyzing the relevant literatures of immune cell metabolism and inflammation regulation in recent years, the metabolic regulatory factors of different immune cell subgroups and the related characteristics of immune cell metabolism in patients with sepsis were summarized. The in-depth understanding of the metabolic state in different immune cells, and the pathophysiological mechanism of septic immune disorders, especially the immune paralysis stage, would provide a theoretical basis for the clinical application of immune metabolic therapy.