Abstract
Background: There are indications that mortality in breast cancer is related with dietary factors, but no study has been large enough to characterise reliably how, this risk is influenced. To establish a logistic regression equation that would predict breast cancer from factors in the endocrinological and metabolic profile, we studied endocrinological and metabolic risk factors that are modified by the diet, in a population of women with breast cancer in southern Spain. Patients and Methods: We carried out a simple a case-control study comparing 204 women with breast cancer (96 premenopausal and 108 postmenopausal women) and 250 healthy control subjects. The predictive variables were basal glycaemia, insulin, glycosylated haemoglobin (HbA1c), C-peptide, insulin-like growth factor-I (IGF-I), total cholesterol, triglycerides, high density lipoprotein-c (HDL-C), low density lipoprotein-c (LDL-C), selenium and Quetelet index (BMI). Results: The metabolic profile differed between pre- and postmenopausal patients, and metabolic alterations were greater in postmenopausal than in premenopausal women. The differences between healthy subjects and breast cancer patients were clearly significant. Conclusions: Our findings have several potential practical applications in the early detection of breast cancer, especially in premenopausal women; in primary prevention; and in the development of a mathematical model of breast carcinogenesis.
Highlights
Breast carcinoma includes a heterogeneous group of tumors with variable prognosis
The metabolic profile differed between pre- and postmenopausal patients, and metabolic alterations were greater in postmenopausal than in premenopausal women
Significant differences were found between patients and control subjects in HbA1c level (p
Summary
Breast carcinoma includes a heterogeneous group of tumors with variable prognosis. International rates of breast cancer between countries suggests that environmental factors, perhaps dietary, may influence the risk of this disease. In Spain, incidence of breast cancer increased is 2.26 times the mortality from this tumour [1] and mortality from breast cancer increased 122% in absolute terms (62% adjusted rate) from 1961 to 1980 [2]. It are look at the changes in Spain during this period in comparison with the preceding years it shows that socioeconomic level increased significantly, and so did food availability and consumption [3]. There are indications that mortality in breast cancer is related with dietary factors, but no study has been large enough to characterise reliably how, this risk is influenced. To establish a logistic regression equation that would predict breast cancer from factors in the endocrinological and metabolic profile, we studied endocrinological and metabolic risk factors that are modified by the diet, in a population of women with breast cancer in southern Spain
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