Abstract
BackgroundThe increase in fructose consumption is paralleled by a higher incidence of metabolic syndrome, and consequently, cardiovascular disease mortality. We examined the effects of 8 weeks of low intensity exercise training (LET) on metabolic, hemodynamic, ventricular and vascular morphological changes induced by fructose drinking in male rats.MethodsMale Wistar rats were divided into (n = 8 each) control (C), sedentary fructose (F) and ET fructose (FT) groups. Fructose-drinking rats received D-fructose (100 g/l). FT rats were assigned to a treadmill training protocol at low intensity (30% of maximal running speed) during 1 h/day, 5 days/week for 8 weeks. Measurements of triglyceride concentrations, white adipose tissue (WAT) and glycemia were carried out together with insulin tolerance test to evaluate metabolic profile. Arterial pressure (AP) signals were directly recorded. Baroreflex sensitivity (BS) was evaluated by the tachycardic and bradycardic responses. Right atria, left ventricle (LV) and ascending aorta were prepared to morphoquantitative analysis.ResultsLET reduced WAT (−37.7%), triglyceride levels (−33%), systolic AP (−6%), heart weight/body weight (−20.5%), LV (−36%) and aortic (−76%) collagen fibers, aortic intima-media thickness and circumferential wall tension in FT when compared to F rats. Additionally, FT group presented improve of BS, numerical density of atrial natriuretic peptide granules (+42%) and LV capillaries (+25%), as well as the number of elastic lamellae in aorta compared with F group.ConclusionsOur data suggest that LET, a widely recommended practice, seems to be particularly effective for preventing metabolic, hemodynamic and morphological disorders triggered by MS.
Highlights
The increase in fructose consumption is paralleled by a higher incidence of metabolic syndrome, and cardiovascular disease mortality
The experimental protocol was approved by the Ethical Committee in Research of the Sao Judas Tadeu University (CEP - Protocol: 063/ 2006), and this investigation was conducted in accordance with the Principles of Laboratory Animal Care formulated by the National Institutes of Health (National Institutes of Health Publication No, 96–23, Revised 1996)
After low intensity exercise training (LET) or following protocols, glycemia remained unchanged in the experimental animals, while F and FT groups showed increased triglyceride levels when compared to C
Summary
The increase in fructose consumption is paralleled by a higher incidence of metabolic syndrome, and cardiovascular disease mortality. Metabolic syndrome (MS), according to International Diabetes Federation [1], is clinically characterized by central obesity, and at least two of these risk factors: high triglyceride levels; low HDL cholesterol; high blood pressure levels; and fasting plasma glucose levels increase These risk factor associations generally are related with increased risk of diabetes [2] and cardiovascular mortality [3]. Clinical and epidemiological evidence suggest a progressive association between fructose consumption and the obesity epidemic along with other abnormalities which are seen in MS [7] In this sense, fructose overload in drinking water or chow has been used to promote metabolic, hemodynamic, structural and functional derangements in rodents. Fructose overload in rats has been linked to negative cardiac remodeling [9], as demonstrated by increased heart-tobody weight ratio, myocyte diameter, as well as left ventricular fibrosis and perivascular collagen type III deposition [12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
