Abstract
Fructose (FR) consumption is a major contributor to obesity and chronic inflammation but its effects have not been widely studied in pregnancy. Pregnancy is a state of systemic inflammation, and increased expression of inflammatory markers in pregnancy has been associated with pre‐eclampsia and other vascular complications; many of these markers may arise from adipose tissue. The study investigated the effect of FR consumption during gestation and its effect on obesity and inflammatory markers (leptin, mass and obesity‐associated (FTO) gene and nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐kB) gene) Female rats received either 10% FR solution (n=18) or tap water (CNTL) (n=17) during gestation. Pregnancies were terminated at gestation day 20; adipose tissue was frozen and total RNA extracted for real time PCR analysis. mRNA abundance was performed for the genes encoding leptin, FTO gene and NF‐kB with housekeeping gene 18s. mRNA expression of FTO (FR:1.75( 0.3; CNTL: 1( 0.1; p<0.05), NF‐?B (FR:1.67( 0.2; CNTL: 1( 0.2; p<0.05) and leptin (FR:2.1( 0.5; CNTL: 1( 0.1; p<0.05) were all upregulated with the FR group. Maternal weight exhibited no difference between the FR and CNTL groups even though markers of obesity and inflammation showed enhanced expression. Further research on inflammatory markers is required to examine the state of systemic inflammation present. Funded by NSERC Canada
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