Abstract
Abstract. In order to determine whether hypoxia is a trigger for changed metabolic activity in muscle tissue, rats were exposed to intermittent hypoxia of varying degree (5% 02, 8% 02, 10% 02, 12% 02, 15% 02 in N2) 3 h per day for 1–4 weeks. The effects of hypoxia on the rate of incorporation of glucose‐carbon into glycogen, lipids, carbon dioxide and lactate and on succinic oxidase activity in skeletal muscle tissue were determined. Rats intermittently exposed to 5% oxygen in nitrogen for one week showed a significant decrease of the rate of incorporation of glucose‐carbon into lipids and carbon dioxide and a significant decrease in succinic oxidase activity. In rats exposed to 8 and 10% 02 a significant increase of the incorporation rate of glucose‐carbon into glycogen, lipids and carbon dioxide was found after 1 and 4 weeks and succinic oxidase activity increased after 4 weeks. The phospholipid concentration in muscle tissue decreased after 8 and 10% 02 exposure for 4 weeks. In the rats exposed to 8% oxygen for 4 weeks the protein concentration of muscle tissue increased significantly.–Based on these results it is suggested that the change of the glycolytic activity and succinic oxidase activity in muscle tissue after physical training and in arterial insufficiency are induced by hypoxia in the muscles.
Published Version
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