Abstract
In this study, we used meta-analysis to comprehensively evaluate the clinical efficacy of Kangfuxin Liquid in the treatment of diabetic patients with skin ulcers. Literature search was performed through PubMed, Web of Science, Embase, China National Knowledge Infrastructure, and Wanfang Data. The retrieval was not limited by language, and the search period was from 2010 to October 12, 2020. Diabetic patients with skin ulcers were treated with Kangfuxin Liquid combined with basic treatment as the treatment group and only basic treatment as the control group. Stata16.0 software was used for system evaluation. A total of 11 studies and 874 patients were included. Meta-analysis showed that 11 studies compared the treatment efficacy between the two groups, and the results showed that the treatment efficacy in the treatment group was significantly higher than that in the control group [OR = 5.38, 95% CI (3.52, 8.24), P < 0.001]. Among them, 9 studies compared the healing time of wounds. The healing time of the treatment group was significantly longer than that of the control group [SMD = −2.13, 95% CI (−2.85, −1.41), P < 0.001]. Five studies compared the length of stay, and the length of stay in the treatment group was shorter than that in the control group [SMD = −3.68, 95% CI (−5.38, −1.97), P < 0.001]. Compared with basic treatment, Kangfuxin Liquid combined with basic treatment has an ideal effect in the treatment of diabetic skin ulcers, which can improve the overall treatment efficiency and shorten the wound rehabilitation time and the length of stay.
Highlights
IntroductionPomegranate has a positive effect on oxidative stress parameters [9]
Meta-analysis showed that 11 studies compared the treatment efficacy between the two groups, and the results showed that the treatment efficacy in the treatment group was significantly higher than that in the control group [Odds ratio (OR) 5.38, 95% confidence interval (CI) (3.52, 8.24), P < 0.001]
53 articles with conference abstracts, case reports, and duplicated data were removed; 11 studies met the selection criteria [5, 14,15,16,17,18,19,20,21,22,23], all of which were Chinese literature. ere were a total of 874 patients, including 440 patients as the treatment group in the trial of Kangfuxin Liquid combined with basic treatment and 434 patients in the control group. e screening process of the literature is shown in Figure 1, and Potentially relavant studies identified and screened for retrieval (n = 173)
Summary
Pomegranate has a positive effect on oxidative stress parameters [9] It provides a reference for the research of Kangfuxin Liquid. It is commonly used in clinical practice to treat various ulcerative diseases [10, 11]. Diabetes mellitus complicated with skin ulcers is common in clinical practice, which often brings great pain to patients. There is no systematic review to evaluate the efficacy of Kangfuxin Liquid in the treatment of diabetic skin ulcers. E aim of this systematic review and meta-analysis of published randomized controlled trials (RCTs) is to evaluate the clinical effects of Kangfuxin Liquid on the treatment of diabetes skin ulcers. We comprehensively and quantitatively compared the advantages and disadvantages of both Kangfuxin Liquid combined with basic treatment and basic treatment on the clinical efficacy of diabetic skin ulcers and explored the optimal treatment for diabetic skin ulcers
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