Meta-analysis of risk factors for lung cancer in Chinese population

Abstract

Objective To investigate the risk factors of lung cancer screening of the Chinese populution and the associated intensity by using Meta analysis, exploratory establishment of a risk assessment model for Chinese populution, for our country crowd lung cancer prevention and formulation of measures to provide basis. Methods Computer retrieval CBM, VIP, ten thousand party, hownet and Pubmed, the Cochrane, EMbase database, supplemented by manual retrieval, literature tracing method. The related literature about Chinese population at home and abroad about lung cancer risk factors were collected from January 1995 to June 2017, the quality of literature was evaluated by USES and Nos scale, and using RevMan5.2 software for Meta analysis. Results A total of 43 literatures in this study were finally included in the Meta-analysis, all of which were case-control studies, and 8 604 cases with total lung cancer were reported, compared with 10 306 cases. Risk factors of lung cancer in Chinese patients with smoking 2.65(1.72-3.98), passive smoking 2.11(1.38- 3.16), passive smoking family 1.73(1.42-2.06), passive smoking workplace 1.54(1.26-1.84), heating soot 1.97(1.51-2.54), indoor decoration 4.99(1.21-6.76), family history of lung cancer 2.62(1.45-4.56), history of tuberculosis 3.42(1.68- 6.66), chronic bronchitis 3.14(1.79-5.32), pickled smoked food 2.67(1.96-3.59), animal innards 2.01(1.56-2.73), type A personality 2.74(1.82-4.01), psychological pressure 2.17(1.54-2.95); protective factors include fresh vegetables 0.27(0.11-0.74), fresh fruits 0.64(0.51-0.83), tea drinking 0.72(0.65-0.85), and physical exercise 0.69(0.54-0.87). Conclusions ①The risk factors of Chinese population for lung cancer are mainly: indoor decoration history, history of trauma, pulmonary tuberculosis, chronic bronchitis, type A personality, pickled smoked acid food, family history of cancer, depressed spirit, smoking, cooking oil fume, psychological stress, depressed, passive smoking, animal offal, heating soot work, family and passive smoking (OR reduced); ②Fresh vegetables, fresh fruit, exercise and tea drinking are protective factors for lung cancer. GSTP1 gene polymorphism and NQO1 gene polymorphism have no relationship with lung cancer; ③ Lung cancer risk factors of Chinese population attribution percentage shows that: the history of interior decoration, high percentage of attribution of mental trauma history, prompt that the occurrence of lung cancer is closely related to the indoor environment pollution and mental factors. Key words: Lung cancer; Risk factors; Chinese population; Meta-analysis