Meta analysis of risk factors for lung cancer in Fuyuan of Yunnan province

Abstract

Objective Fuyuan is one of the areas with highest prevalence of lung cancer in China.The present study analyzed the main risk factors for high incidence of lung cancer in Fuyuan to direct future lung cancer prevention.Methods We reviewed previous studies on lung cancer in Fuyuan of Yunnan province from January 1995 to December 2011.by searching Pubmed,Web of knowledge,Google,Chinese National Knowledge Infrastructure and ChinaInfo.The Meta analysis was done using RevMan 4.2.Results A total of 12 studies involving 4666 patients and 5298 controls were included.The pooled odd ratio (OR) values were 4.40 (indoor coal pollution),2.15 (ventilation in kitchen),2.02(exposure to coal-mine production),1.72 (smoking),1.70 (second hand smoke for women),1.65(genetic susceptibility,family history),1.52 ( certain pulmonary diseases),1.39 (diet,cholesterol,alcohol),and 0.65 (vegetables and fruits).Conclusions The main risk factors for lung cancer are environmental pollution,smoking,family history,certain pulmonary diseases and diet.Environmental pollution and genetics contribute to development of lung cancer in Fuyuan of Yunnan province in China. Key words: Lung cancer; Risk factors; Meta analysis; Fuyuan area