Abstract
Objectives: TP53 is an important tumor suppressor gene to maintain genomic integrity, and its mutations increase the susceptibility to oral carcinoma. Previous published studies have reported the relation of TP53 codon 72 polymorphism with the risk of oral carcinoma, but the results remain controversial and inconclusive.Methods: We therefore utilized meta-analysis based on a comprehensive search in PubMed, EMBASE, and Google of Scholar databases up to August 19, 2017.Results: Total 3,525 cases and 3,712 controls from 21 case-control studies were selected. We found no significant association between TP53 codon 72 polymorphism and oral carcinoma susceptibility in all genetic contrast models, including subgroup analysis based on control source and ethnicity. Furthermore, TP53 codon 72 polymorphism was not significant associated with oral carcinoma susceptibility in tobacco or alcohol use, and HPV infection status. Our results were confirmed by sensitivity analysis and no publication bias was found.Conclusions: Taken together, our data indicate that TP53 codon 72 polymorphism is not associated with the susceptibility to oral carcinoma.
Highlights
Based on the GLOBOCAN2012 investigations, oral carcinoma is regarded as one of the most common causes of cancer related morbidity and mortality, contributing to 3.8% of all cancer cases and 3.6% of cancer related deaths (Warnakulasuriya, 2009; Ferlay et al, 2015; Shield et al, 2017)
Not all individuals exposing to these risk factors are subject to oral carcinoma, and additional genetic factors may contribute to oral carcinoma susceptibility (Chen et al, 2010; Anantharaman et al, 2011; Niu et al, 2012)
Inclusion criteria were: (i) evaluated the association between tobacco and/or alcohol uses, TP53 codon 72 polymorphism, Human papillomavirus (HPV) infection, and susceptibility to oral carcinoma; (ii) case-control researches published in English or Chinese; (iii) definite histopathologic diagnosis or clearly reported
Summary
Based on the GLOBOCAN2012 investigations, oral carcinoma is regarded as one of the most common causes of cancer related morbidity and mortality, contributing to 3.8% of all cancer cases and 3.6% of cancer related deaths (Warnakulasuriya, 2009; Ferlay et al, 2015; Shield et al, 2017). The long-term survival rate of oral carcinoma is
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