Meta analysis on randomized controlled trial of modified Shengmai decoction treating viral myocarditis

Abstract

Objective To study the effect of modified Shengmai decotion treating viral myocarditis, and on the basis of syndrome differentiation, to discuss the type and period for treating VM. Methods The PubMed, Embase, the Cochrane Library, the Chinese biomedical literature database(SinoMed), China hownet(CNKI), and VIP database(VIP) were retrieved for the articles on VM treated by modified Shengmai decoction with RCT method. RevMan 5.0 software was adopted for Meta-analysis. Results A total of 7 articles and 495 patients were involved. The results showed the modified Shengmai decoction treatment group had statistical difference to the control group in treating VM [OR(95% CI) was 3.61 (2.11,6.16), Z=4.70, P<0.01]. Among them, the decoctions containing milkvetch root or not had statistical difference compared to the control group[containing milkvetch root [OR (95% CI) was 2.67 (1.29, 5.52), Z=2.64, P=0.008; not containing milkvetch root OR (95% CI) was 5.11 (2.30,11.38), Z=3.99, P<0.01]. Conclusion Modified Shengmai decoction has certain effects in treating VM of Qi and yin deficiency type or VM in the advanced stage showing Qi and yin deficiency. The effectiveness of adding milkvetch root in Shengmai decoction to treat VM should be further discussed, the use of milkvetch root must be based on the premise of careful syndrome differentiation. Key words: Modified Shengmai decoction; Viral myocarditis; Meta-analysis